In the United States, FDA guidelines indicate these medications for: Adults with a BMI of 30 or higher (obesity) Adults with a BMI of 27 or higher who also have at least one weight-related health condition, such as type 2 diabetes, high blood pressure, high cholesterol, or obstructive sleep apnea You should discuss GLP-1 medications with a physician if you have any of the following, as they may affect which medication is appropriate or require additional monitoring: Personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) a contraindication for all GLP-1 drugs History of pancreatitis Kidney disease or a history of gallstones Pregnancy or plans to become pregnant History of eating disorders The Critical Factor Most People Overlook: Muscle Loss Here is something that rarely appears in GLP-1 marketing: these medications can cause significant muscle loss alongside fat loss, particularly at the aggressive weight loss rates they enable

Cell Metab 23(4): 591-601
These insights help your clinician personalize your starting dose and titration schedule for optimal results based on your unique biology
93 : 453459 Bieber LL
Strategy 3: Slow Titration (Half-Steps Between Doses) What it is : Some clinicians prescribe intermediate titration steps using available pen strengths
le Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V